Protective effect of esculetin against oxidative stress-induced cell damage via scavenging reactive oxygen species
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چکیده
منابع مشابه
Protective Effect of Fisetin (3,7,3',4'-Tetrahydroxyflavone) against γ-Irradiation-Induced Oxidative Stress and Cell Damage
Ionizing radiation can induce cellular oxidative stress through the generation of reactive oxygen species, resulting in cell damage and cell death. The aim of this study was to determine whether the antioxidant effects of the flavonoid fisetin (3,7,3',4'-tetrahydroxyflavone) included the radioprotection of cells exposed to γ-irradiation. Fisetin reduced the levels of intracellular reactive oxyg...
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Oxidative stress, as mediated by ROS, is a significant factor in initiating the development of age-associated cataracts; D-limonene is a common natural terpene with powerful antioxidative properties which occurs naturally in a wide variety of living organisms. It has been shown to have antioxidant effect; we found that D-limonene can effectively prevent the oxidative damage caused by H2O2 and p...
متن کاملReactive oxygen species and oxidative DNA damage.
Reactive oxygen species (ROS) such as the superoxide anion radical (O2.-) hydrogen peroxide (H2O2) and hydroxyl radical (.OH) have been implicated in the pathophysiology of various states, including ischemia reperfusion injury, haemorrhagic shock, atherosclerosis, heart failure, acute hypertension and cancer. The free radicals, nitric oxide (NO) and O2.- react to form peroxynitrite (ONOO-), a p...
متن کاملReactive oxygen species: Oxidative damage and pathogenesis
Reactive oxygen species (ROS) such as O2 – , H2O2 and .OH are highly toxic to cells. Cellular antioxidant enzymes, and the free-radical scavengers normally protect a cell from toxic effects of the ROS. However, when generation of the ROS overtakes the antioxidant defense of the cells, oxidative damage of the cellular macromolecules (lipids, proteins, and nucleic acids) occurs, leading finally t...
متن کاملProtective Effect of an Isoflavone, Tectorigenin, Against Oxidative Stress-induced Cell Death via Catalase Activation
BACKGROUND Isoflavones are biologically active compounds that occur naturally in a variety of plants, with relatively high levels in soybean. Tectorigenin, an isoflavone, protects against hydrogen peroxide (H2O2)-induced cell damage. However, the underlying mechanism is unknown. METHODS The MTT assay was performed to determine cell viability. Catalase activity was assessed by determining the ...
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ژورنال
عنوان ژورنال: Acta Pharmacologica Sinica
سال: 2008
ISSN: 1671-4083,1745-7254
DOI: 10.1111/j.1745-7254.2008.00878.x